New patients save $50 on the first vial with code FAST50

SkinTretinoin from DrBrainRx

Sexy Brain · Skin

Prescription tretinoin cream

★★★★★4.9/5 average rating · 10,000+ patients treated

Prescription-strength retinoid for acne, fine lines, uneven texture and sun damage. Available in a gentle and a stronger strength.

From $95one-time
  • ✓Not over-the-counter retinol
  • ✓Prescribed after a quick online intake
  • ✓No subscription required
Gentle 0.025% · $95Stronger 0.05% · $110

No subscription required. Purchasing does not guarantee a prescription; treatment is prescribed only when medically appropriate.

✓ Triple board-certified physician✓ Licensed 503A U.S. pharmacies✓ Cold-packed overnight shipping✓ No insurance required✓ Cancel anytime

About Tretinoin

One of dermatology's most studied ingredients

Tretinoin is a prescription-strength topical retinoid derived from vitamin A. It increases skin cell turnover and stimulates collagen, helping improve acne, fine lines, uneven texture and visible signs of sun damage.

Unlike over-the-counter retinol, tretinoin is an active form of retinoic acid that works directly on receptors in the skin.

The gentle strength is commonly used when starting tretinoin or when a gradual approach is preferred. The stronger strength is often used by patients who already tolerate tretinoin or need a higher concentration. Your provider recommends the right one.

Potential benefits

  • ✓Reduces fine lines and improves the appearance of photoaged skin
  • ✓Stimulates collagen and improves firmness
  • ✓Smooths uneven texture and roughness
  • ✓Helps clear acne and prevent clogged pores
  • ✓Promotes a more even-looking skin tone
  • ✓Helps reduce certain dark spots caused by sun damage
How it's used

Tretinoin is applied to the face at night, as directed by your provider. Many people start slowly and build up as their skin adjusts.

  • Apply to clean, completely dry skin
  • Follow with moisturizer to limit dryness and irritation
  • Use broad-spectrum SPF 30+ sunscreen every morning

How often you apply it is based on your skin sensitivity, goals and response.

Results are gradual. Acne improvement may show within 8 to 12 weeks, while fine lines and photoaging usually take several months of consistent use.

Product details
  • Compounded topical cream
  • Gentle or stronger strength, chosen with your provider
  • Roughly a one- to two-month supply, depending on how much and how often you apply
  • Prescription-strength topical retinoid
  • Prepared by a licensed compounding pharmacy
  • For external use only
  • Requires a medical intake and provider review
  • Compounded tretinoin is not FDA approved
Important safety information
  • Requires a medical intake and provider approval
  • May cause dryness, peeling, redness, irritation and increased sun sensitivity
  • Avoid broken, sunburned or severely irritated skin
  • Avoid the eyes, lips and mucous membranes
  • Do not use during pregnancy or while trying to conceive; ask your provider about breastfeeding
  • Daily sunscreen is essential
  • Compounded medications are not FDA approved
Who can get it

Purchasing does not guarantee a prescription. Treatment is prescribed only when medically appropriate.

You must be physically located in a state where DrBrainRx is licensed at the time of prescribing. Shipping availability depends on pharmacy licensing and applicable state requirements.

Current prescribing states: CA, FL, KY, ME, MA, MI, MN, MT, NV, NH, NY, OH, RI, SC, TX, UT, WY, CO, NC, IN, NE.

Patient reviews

Real support from a team that answers

4.9/5

Average rating

99%

Of patients recommend us

10,000+

Patients treated across the US

★★★★★

“Fastest and kindest medical team I’ve ever worked with. Every text got a response within minutes. No waiting rooms, no confusion.”
Michael R. · DrBrainRx patient

★★★★★

“Finally a team that actually listens. The meds helped my hunger, but the support helped my life.”
Lauren K. · DrBrainRx patient

★★★★★

“I didn’t just lose weight, I gained confidence. I’m more energetic, sleeping better, and I feel strong again.”
Amanda S. · DrBrainRx patient

★★★★★

“Everything prescribed online and delivered to my door. The most convenient and supportive program I’ve ever tried.”
Danielle T. · DrBrainRx patient
Read more reviews →

Tretinoin FAQ

Questions about tretinoin

Which strength should I choose?

Start with the gentle strength if you are new to tretinoin or have sensitive skin. Your provider confirms the right strength during review.

How is this different from retinol?

Retinol has to be converted in the skin. Tretinoin is the active form, so it works directly and is prescription-only.

Do I need a prescription?

Yes. You complete a short online intake and a licensed provider reviews it before anything ships.

What does it cost?

$95 for the gentle strength and $110 for the stronger strength. No subscription required.

Gentle 0.025% · $95